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Symbol Name ID |
Trio
triple functional domain (PTPRF interacting) MGI:1927230 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Dysphagia |
Tremor |
Delayed speech and language development |
Poor speech |
Autistic behavior |
Aggressive behavior |
Compulsive behaviors |
Attention deficit hyperactivity disorder |
Motor stereotypy |
Self-injurious behavior |
Hyperacusis |
Intellectual disability |
Hyperreflexia |
Motor delay |
Delayed ability to walk |
Seizure |
Pain insensitivity |
| Disease(s) Associated with TRIO | ||||||||||||||||||
| autosomal dominant intellectual developmental disorder 44 |
| Mouse Phenotypes | nervous system phenotype |
increased neuron apoptosis |
abnormal neuron differentiation |
abnormal neuronal migration |
abnormal cerebellar granule cell migration |
abnormal cerebellum external granule cell layer morphology |
abnormal rostral migratory stream morphology |
decreased brain size |
abnormal dentate gyrus morphology |
abnormal olfactory bulb morphology |
abnormal olfactory bulb mitral cell layer morphology |
small olfactory bulb |
abnormal Bergmann glial cell morphology |
abnormal cerebellar granule layer morphology |
abnormal cerebellar granule cell morphology |
abnormal cerebellum lobule morphology |
small cerebellum |
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| Availability | Mouse Genotype | |||||||||||||||||
| Triotm1Mst/Triotm1Mst | ||||||||||||||||||
| Tg(GFAP-cre)#Mzhu/0 Triotm1Mzhu/Triotm1Mzhu (conditional) |
* | |||||||||||||||||
| Tg(Nes-cre)1Kln/0 Triotm1Mzhu/Triotm1Mzhu (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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